Inherent Anti-amyloidogenic Activity of Human Immunoglobulin Heavy Chains*
نویسندگان
چکیده
Sharad P. Adekar, Igor Klyubin, Sally Macy, Michael J. Rowan, Alan Solomon, Scott K. Dessain, and Brian O’Nuallain From the Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, the Trinity College Institute of Neuroscience and Department of Pharmacology and Therapeutics, Trinity College, Dublin 2, Ireland, and the Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920
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تعیین اپی توپ های ناپیوسته زنجیره سبک ایمونوگلوبولین انسان توسط ایمونولوژی محاسبه ای
Background: Immunoglobulins are a group of proteins that have important role in defense against microorganisms. Immunoglobulins consist of heavy and light chains. In human, immunoglobulin light chain comprises of two isotypes: Kappa (K) and lambda (λ) based on amino acid differences in carboxylic end of their constant region. Marked changes in the K to λ ratio can happen in monocl...
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